目的本文报道分析了维甲酸联合放射治疗与单纯放射治疗，对中晚期肺腺癌的疗效及放射治疗期间的毒副反应。方法从１９９４年１月至１９９５年１月收治中晚期肺腺癌２０例，１０例维甲酸加放疗，１０例单纯放射治疗，两组均用直线加速器，常规分割放射治疗，肿瘤量６０～７０Ｇｙ／６～７周，维甲酸加放疗组，放疗前１０～２０分钟口服维甲酸３０～６０ｍｇ／ｍ２。从放疗开始连服４６天为１周期，放疗结束后休息７～１４天重复１个周期。结果维甲酸加放疗组：ＣＲ６０％，ＰＲ２０％，Ｓ２０％；单纯放疗组：ＣＲ４０％，ＰＲ４０％，Ｓ２０％。在治疗过程中观察血象，肝、肾功能、胃肠道反应两组均未发现明显毒反映。结论结果显示放疗加维甲酸治疗中晚期肺腺癌疗效优于单纯放射治疗，其机理在于维甲酸使Ｇ１期延滞和Ｇ２～Ｓ期转换受到抑制，使癌细胞阻断于对放射线敏感的Ｇ１期增加放疗效果，使肿瘤消失变快 Objective To analyze the efficacy of retinoic acid combined with radiotherapy and radiotherapy alone on the treatment of advanced lung adenocarcinoma and the toxic and side effects during radiotherapy. Methods From January 1994 to January 1995, 20 patients with advanced adenocarcinoma of the lung were treated. 10 patients received retinoic acid plus radiotherapy and 10 patients received radiotherapy alone. The two groups used a linear accelerator to divide the radiotherapy. The tumor volume was 60 to 70 Gy. / 6 ~ 7 weeks, retinoid plus radiotherapy group, 10 to 20 minutes before radiotherapy oral retinoid 30 ~ 60mg/m2. From the start of radiotherapy, it took 46 days for 1 cycle, and after the end of radiotherapy, it took 7 to 14 days to repeat one cycle. Results Retinoic acid plus radiotherapy group: CR60%, PR20%, S20%; Radiotherapy alone group: CR40%, PR40%, S20%. During the course of treatment, blood was observed, and liver, kidney function, and gastrointestinal reactions did not show any obvious toxic response. Conclusion The results show that radiotherapy plus retinoids is superior to radiotherapy alone in the treatment of advanced lung adenocarcinoma. The mechanism is that retinoids inhibit the transition from G1 to G2 to S phase transition and block the radiation-sensitive G1 phase. Increase the effect of radiotherapy, so that the tumor disappears faster