Interactive picking is a fundamental task for processing digital graphics and images.Combining two-dimensional (2D) and three-dimensional (3D) views is an important trend in processing medical sliced-geometries.With the goal of accurately picking points in sliced-geometries,we present a method to pick points interactively by combining 2D and 3D views of sliced-geometries.Four view windows are constructed to render sliced-geometries using medical imaging interaction toolkit (MITK):three for 2D slices parallel to the XY,YZ,and XZ planes and one for surface rendering.Points picked in a view window can be rendered and modified in any window.After a point is picked,it is immediately converted into a world coordinate and stored.Points are only rendered and modified based on their world coordinates.This picking method can be used for fitting,observing,and measuring local regions.This method can also be used for interactive segments.Our experiment shows that the picking method is accurate and has a real-time picking effect.