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本文旨在研究前扣带皮层(anterior cingulate cortex,ACC)电刺激对Sprague-Dawley(SD)大鼠丘脑腹侧基底核(ventrobasalnucleus,VB)神经元自发放电活动的影响。实验采用在体细胞外记录法,以不同的电刺激参数刺激SD大鼠ACC(25、32及24区),观察VB神经元自发放电活动的变化。结果显示,以不同延迟时间电刺激ACC,VB神经元(12/53,22.6%)在ACC刺激后不同时程内自发放电活动完全被抑制;其抑制效应与ACC刺激的强度呈现量效关系,在适当范围内,电刺激强度增大和脉冲数增加,VB神经元自发放电活动被完全抑制的时程均明显延长;ACC电刺激对VB神经元自发放电活动抑制性影响形式多样,并具有累积效应。以上结果提示,ACC电刺激对丘脑VB神经元自发放电活动具有抑制性影响。
The aim of this study was to investigate the effect of anterior cingulate cortex (ACC) electrical stimulation on the spontaneous firing of ventrobasal nucleus (VB) neurons in the thalamic nucleus of Sprague-Dawley rats. In the experiment, extracellular recording method was used to stimulate the ACC (25, 32 and 24 zones) of SD rats with different electrical stimulation parameters to observe the changes of spontaneous firing activities of VB neurons. The results showed that ACC and VB neurons (12 / 53,22.6%) with different delay time were completely inhibited in spontaneous firing activities after ACC stimulation for different time points. The inhibitory effect showed a dose-response relationship with the intensity of ACC stimulation, Within the appropriate range, the electrical stimulation intensity and the number of pulses increased, VB neurons completely suppressed spontaneous discharge activity were significantly extended duration; ACC electrical stimulation of VB neurons spontaneous discharge activity in a variety of forms, and has a cumulative effect . These results suggest that ACC electrical stimulation of thalamus VB neurons spontaneous discharge activity has an inhibitory effect.