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目的探讨微生态调节剂整肠生和乳果糖在慢性重型肝炎的治疗作用。方法 162例慢性重型肝炎患者被随机分为治疗组(84例)和对照组(78例)。对照组给予常规的综合治疗,治疗组在对照组的基础上给予整肠生胶囊4粒、乳果糖口服液10 ml每日3次口服,疗程为4周。比较2组病例治疗后主要症状和体征、肝功能、凝血功能、内毒素、血氨、并发症发生率及病死率。结果与对照组比较,治疗组更有效地改善患者临床症状、肝功能及凝血功能,降低血浆内毒素、血氨浓度,减少自发性腹膜炎(SBP)、肝性脑病(HE)和肝肾综合征(HRS)等并发症发生率和患者病死率。结论微生态制通过调整肠道失调菌群,能改善患者肝功能和凝血功能,降低血氨和内毒素血症,减少并发症和病死率,对慢性重型肝炎有明显治疗作用。
Objective To investigate the therapeutic effect of microecological conditioning agents, intestinal and lactulose, on chronic severe hepatitis. Methods 162 patients with chronic severe hepatitis were randomly divided into treatment group (84 cases) and control group (78 cases). The control group was given conventional comprehensive treatment. The treatment group was given 4 capsules of whole intestines, 10 ml of lactulose oral solution 3 times daily for 4 weeks on the basis of the control group. The main symptoms and signs, liver function, coagulation function, endotoxin, blood ammonia, complication rate and mortality were compared between the two groups. Results Compared with the control group, the treatment group was more effective in improving clinical symptoms, liver function and coagulation function, reducing plasma endotoxin, blood ammonia concentration, reducing spontaneous peritonitis (SBP), hepatic encephalopathy (HE) and hepatorenal syndrome (HRS) and other complications and patient mortality. Conclusion Microecology can improve the hepatic function and blood coagulation function, reduce the blood ammonia and endotoxemia, reduce the complication and mortality, and have a significant therapeutic effect on chronic severe hepatitis by adjusting intestinal flora.