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目的探讨免疫荧光标记的方法快速床旁测定脑钠肽(BNP)对心力衰竭(以下简称心衰)分期的临床应用价值。方法选择196例心衰危险人群和心衰竭患者,进行心衰分期并利用荧光免疫法快速测定BNP,进行心功能分级(NYHA)、超声心动图检测,观察不同分期血浆BNP水平的改变、NYHA分级、左心室射血分数(LVEF)及治疗前后的变化。结果血浆BNP水平随着心功能损坏程度的加重而逐渐增高,在不同心衰分期之间差异均有统计学意义。同时在心力衰竭期(C期、D期),无论射血分数是否小于50%,血浆BNP水平均明显高于心衰危险期(A期、B期),差异有统计学意义。心力衰竭期患者经过抗心衰治疗后,血浆脑钠肽浓度下降,NYHA心功能分级显著降低,LVEF值上升,差异有统计学意义。结论快速床旁血浆脑钠肽测定在心衰诊断、分期、治疗效果及预后判断中具有较高的应用价值。
Objective To investigate the clinical application of immunofluorescence labeling in rapid determination of brain natriuretic peptide (BNP) in patients with heart failure (hereinafter referred to as heart failure) staging. Methods A total of 196 patients with heart failure and heart failure were enrolled in this study. The BNP level was determined by FACS and NYHA and echocardiography were performed. The changes of plasma BNP level at different stages were observed. , Left ventricular ejection fraction (LVEF) and changes before and after treatment. Results Plasma BNP levels gradually increased with the severity of cardiac dysfunction, and there were significant differences in different stages of heart failure. At the same time, in the period of heart failure (stage C and D), plasma BNP levels were significantly higher than those in the risk of heart failure (stage A and stage B) regardless of the ejection fraction less than 50%. The difference was statistically significant. Heart failure patients after anti-heart failure treatment, plasma brain natriuretic peptide concentration decreased, NYHA cardiac function was significantly reduced, LVEF values increased, the difference was statistically significant. Conclusion The rapid determination of plasma BNP by bedside has high value in the diagnosis, staging, therapeutic effect and prognosis of heart failure.