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目的 :探讨 2型糖尿病 (DM)合并冠心病 (CHD)与血管紧张素转化酶 I(ACE)基因插入 /缺失 (I/ D)多态性的相关性及其各基因型血脂代谢情况。方法 :采用多聚酶链反应 (PCR)技术 ,对 32例广西地区汉族 2型 DM合并 CHD患者 ,88例 2型DM无合并 CHD患者及 10 0名汉族正常对照的 ACE基因 I/ D多态性及血脂进行检测。结果 :2型 DM合并 CHD组 ACE基因 D等位基因及 ID基因型发生频率高于正常对照组及无合并 CHD组 (P <0 .0 5 ) ;I等位基因及 II基因型频率低于正常对照组及无合并 CHD(P <0 .0 5 )。 2型 DM合并 CHD组 ID基因型组甘油三酯 (TG)及总胆固醇 (TC)高于正常对照组、DD基因型组及 II基因型组 ,高密度脂蛋白胆固醇 (HDL- C)低于正常对照组 ,低密度脂蛋白胆固醇 (L DL- C)高于正常对照组 (P <0 .0 5 ) ;2型 DM合并 CHD DD基因型组 TG、L DL- C及 TC高于正常对照组 (P <0 .0 5 )。结论 :1广西地区汉族 2型 DM合并 CHD与 ACE基因 I/ D多态性有关。 2 D等位基因及 ID基因型可能为 2型 DM合并 CHD的易感基因 ,I等位基因及 II基因型可能为 2型 DM合并 CHD的保护基因。 3广西地区汉族 2型 DM合并 CHD的 ID基因型者及 DD基因型者易合并高甘油三酯血症及高胆固醇血症
Objective: To investigate the relationship between type 2 diabetes mellitus (DM) with coronary heart disease (CHD) and angiotensin I converting enzyme (ACE) gene insertion / deletion (I / D) polymorphisms and the lipid metabolism of each genotype. Methods: Polymerase chain reaction (PCR) was used to detect the ACE gene I / D polymorphism in 32 cases of type 2 DM with CHD, 88 cases of type 2 DM without CHD and 100 normal Han controls in Guangxi. Blood lipids were tested. Results: The frequencies of D allele and ID genotype of ACE gene in type 2 DM combined CHD group were higher than those in control group and without CHD group (P <0.05). The frequency of I allele and II genotype was lower than Normal control group and without CHD (P <0.05). Type 2 DM combined with CHD group ID genotype triglyceride (TG) and total cholesterol (TC) than the normal control group, DD genotype group and genotype II group, high-density lipoprotein cholesterol (HDL-C) The levels of TG, L DL-C and TC in type 2 DM combined with CHD DD genotype were higher than those in normal control group, normal control group and low-density lipoprotein cholesterol (L DL-C) Group (P <0.05). Conclusion: 1 Guangxi Han type 2 DM combined with CHD ACE gene I / D polymorphism. 2 D allele and ID genotype may be susceptible genes of type 2 DM combined with CHD, and I allele and II genotype may be protective genes of type 2 DM combined with CHD. 3 Guangxi Han Chinese type 2 DM with CHD ID genotypes and DD genotypes easily combined with hypertriglyceridemia and hypercholesterolemia