目的:观察补肾益脑方联合左旋多巴胺治疗肝肾不足,痰瘀阻络证帕金森病(PD)的临床疗效及对氧化应激和炎症反应的影响。方法:将80例PD患者采用随机按数字表法分为对照组和观察组各40例。对照组采用复方卡比多巴片和司来吉兰片治疗,观察组在对照组治疗的基础上加用补肾益脑方内服。两组疗程均为6个月。进行治疗前后帕金森病评定量表(UPDRS),帕金森病生活质量量表(PDQ-39),焦虑自评量表(SAS),抑郁自评量表(SDS),中医证候评分,检测治疗前后超氧化物歧化酶(SOD),丙二醛(MDA),白细胞介素-1β(IL-1β)和IL-6水平。结果:观察组临床疗效总有效率为87.5%,优于对照组的72.5%(P<0.05);治疗后观察组UPDRSⅠ-Ⅳ评分均低于对照组(P<0.01);治疗后观察组PDQ-39SI,中医证候评分,SAS和SDS均低于对照组(P<0.05,P<0.01);治疗后观察组IL-1β,IL-6和MDA水平低于对照组,SOD水平高于对照组(P<0.01)。结论:补肾益脑方联合左旋多巴胺能改善PD(肝肾不足,痰瘀阻络证)运动症状和非运动症状,提高患者生活质量,减轻药物副反应,临床疗效优于单纯西药治疗,其作用机制可能通过减轻氧化应激和炎症反应来实现的。 Objective: To observe the clinical effects of Bushen Yibanfang combined with levodopa in the treatment of liver and kidney insufficiency, and the effect of phlegm stasis and collaterals on Parkinson’s disease (PD) and its effects on oxidative stress and inflammatory reaction. Methods: Eighty PD patients were randomly divided into control group and observation group according to the digital table method. The control group was treated with carbidopa compound tablets and selegiline tablets. The observation group was treated with Bushen Yibai Recipe in the control group. Two courses of treatment are 6 months. Pre-and post-treatment UPDRS, PDQ-39, SAS, SDS, TCM syndrome score, Before and after treatment, the levels of superoxide dismutase (SOD), malondialdehyde (MDA), interleukin-1β (IL-1β) and IL-6 were measured. Results: The total effective rate of observation group was 87.5%, which was better than that of control group (P <0.05). After treatment, UPDRS Ⅰ-Ⅳ scores in observation group were lower than those in control group (P <0.01) -39SI, SAS and SDS were lower than the control group (P <0.05, P <0.01); the levels of IL-1β, IL-6 and MDA in the observation group were lower than those in the control group Group (P <0.01). Conclusion: Bushen Yibanfang combined with levodopa can improve motor symptoms and non-motor symptoms of PD (liver and kidney deficiency, phlegm and blood stasis syndrome), improve quality of life of patients and reduce side effects of drugs, and its clinical curative effect is superior to that of western medicine alone. Mechanism may be through the reduction of oxidative stress and inflammatory response to achieve.