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目的:探讨幽门螺杆菌(Hp)与儿童自身免疫性甲状腺病(AITD)的关系。方法:选取信宜市人民医院2014年4月至2016年10月收治的确诊为AITD的患儿为研究对象,根据不同的甲状腺功能分为A、B、C 3组,另选取同时期排除AITD的儿童共100例作为对照组(D组)。检测四组Hp抗体免疫球蛋白G(IgG)和免疫球蛋白A(IgA)及甲状腺过氧化物酶抗体(TPOAb)和甲状腺球蛋白抗体(TgAb)的水平、逐一记录并进行统计学分析。结果:A、B、C三组Hp感染率分别为82.35%、68.75%、65.00%,均显著高于D组的39.00%,差异具有统计学意义(P<0.05);A、B、C3组之间Hp感染率比较,差异均无统计学意义(P>0.05);AITD组中Hp的IgG、IgA同TPOAb、TgAb存在正相关关系。结论:幽门螺旋菌感染同儿童甲状腺自身抗体的水平呈正相关,提示幽门螺旋菌感染可能是儿童自身免疫性甲状腺病的发病因素。
Objective: To investigate the relationship between Helicobacter pylori (Hp) and childhood autoimmune thyroid disease (AITD). Methods: The children with AITD who were treated in Xinyi People’s Hospital from April 2014 to October 2016 were selected as study subjects, divided into A, B and C groups according to different thyroid functions, and the other groups were excluded from AITD Of 100 children as a control group (D group). The levels of Hp antibody IgG, IgA, TPOAb and TgAb in the four groups were detected and statistically analyzed. Results: The infection rates of Hp in group A, B and C were 82.35%, 68.75% and 65.00%, respectively, which were significantly higher than those in group D (39.00%, P <0.05) (P> 0.05). There was a positive correlation between Hp IgG, IgA and TPOAb, TgAb in AITD group. Conclusion: Helicobacter pylori infection is positively correlated with thyroid autoantibodies in children, suggesting that H. pylori infection may be the causative factor of childhood autoimmune thyroid disease.