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目的探讨24h食管pH监测在新生儿胃食管反流(GER)中的应用和临床意义。方法采用便携式pH自动记录仪,对30例疑诊为GER的新生儿行24h食管pH监测;以无症状的新生儿10例作为对照组。结果GER组各项反流指标与对照组有显著性差异。新生儿病理性GER临床表现以呕吐(溢乳)最常见(95·5%),其次为呼吸暂停(发作青紫)(22·7%)和呛咳(4·5%);除单纯病理性GER及消化道畸形为主要病因外,新生儿窒息及败血症也与其关系密切。结论GER有多种临床表现,行24h食管pH监测是早期诊断新生儿GER的较好方法。GER可由多种疾病引起,应积极寻找病因,选择适宜的治疗方法。
Objective To investigate the application and clinical significance of 24h esophageal pH monitoring in neonatal gastroesophageal reflux disease (GER). Methods A portable pH automatic recorder was used to monitor the esophageal pH of the 30 newborns suspected of GER for 24 hours. Ten asymptomatic newborns were used as the control group. Results The GER group of reflux indicators and the control group were significantly different. The clinical manifestations of neonatal pathological GER were vomiting (95.5%), followed by apnea (22.7%) and cough (4.5%). In addition to simple pathological GER And gastrointestinal malformations as the main cause, neonatal asphyxia and septicemia are also closely related. Conclusions There are many clinical manifestations of GER. A 24-hour esophageal pH monitoring is a good method for early diagnosis of neonatal GER. GER can be caused by a variety of diseases, should actively find the cause, choose the appropriate treatment.