本文报告一例女性、17岁、急性系统性红斑性狼疮,未经类固醇激素或免疫抑制剂治疗,也未经关节腔内注射治疗而发生化脓性关节炎,膝关节脓液培养为A组溶血性链球菌,经青、链霉素治疗而愈,但患者虽经类固醇激素和免疫抑制剂苯丁酸氮芥治疗终于在一年后死亡。作者指出系统性红斑狼疮并发化脓性关节炎的并不多见。作者复习了1940年以来的国际文献仅见8例报道,其中除一例男性外,均为女性,年龄在18至34岁之间。狼疮诊断在脓毒性关节炎之前(18个月到16年)。膝关节是最常受累的关节,可单独受累或为多发性关节炎中的一个组成部分,仅一例 This article reports a female, 17 years old, with acute systemic lupus erythematosus who developed septic arthritis without steroid or immunosuppressive agents and who developed septic arthritis without intra-articular injections. The knee joint pus culture was hemolytic in group A Streptococcus, through blue, streptomycin treatment and more, but although the patient after steroid hormone and immunosuppressive agents chlorambucil treatment finally died in one year. The authors point out that systemic lupus erythematosus complicated with suppurative arthritis is rare. The authors reviewed only 8 reports of international literature since 1940, except for one male, both female and between 18 and 34 years of age. Lupus was diagnosed before septic arthritis (18 months to 16 years). The knee is the most commonly affected joint, either alone or as a component of polyarthritis, with only one