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目的：观察坦度螺酮联合艾司西酞普兰治疗强迫症的疗效和安全性。方法将64例强迫症患者随机分为观察组和对照组各32例。观察组采用坦度螺酮联合艾司西酞普兰治疗，对照组单一使用艾司西酞普兰治疗。对比2组临床疗效。于治疗前后使用Y－BOCS和汉密顿焦虑（ HAMA）量表评定患者的强迫症和焦虑症精神症状。于治疗前及治疗后第1、4、8周末使用副反应量表（ TESS ）评定2组患者的不良反应情况。结果治疗前2组患者的Y－BOCS评分及HAMA总分比较差异无统计学意义（P＞0．05）。治疗后2组患者的Y－BOCS评分及HAMA评分均低于治疗前，且观察组低于对照组，差异均有统计学意义（P＜0．05）。治疗后观察组患者的总有效率为93．75％显著高于对照组患者的59．38％，差异有统计学意义（P＜0．05）。治疗后第1、4、8周末2组患者TESS评分比较差异均无统计学意义（ P＞0．05）。结论坦度螺酮联合艾司西酞普兰治疗强迫症能有效缓解强迫、焦虑症状，安全有效，且不增加不良反应发生率。“,”Objective To observe the clinical effect of tandospirone combined escitalopram in obsessive -compulsive disorder.Methods 64 cases patients with obsessive-compulsive disorder were randomly divided into observation group and control group,each of 32 cases.Observation group was treated by tandospirone combined escitalopram .Control group was trea-ted by escitalopram.After treatment,compared the clinical effect of 2 groups.The obsessive-compulsive disorder was assessment by YBOCS scale,the anxiety was assessment by HAMA scale .Assessment the adverse reactions of 1,4,8 weeks by TESS scale before and after treatment of 2 groups.Results The YBOCS and HAMA score before treatment was no statistically significant (P>0.05).The YBOCS and HAMA score after treatment of 2 groups were lower than that before treatment ,and the YBOCS and HAMA score of observation group were lower than that of control group ,the difference was statistically significant ( P<0.05).After treatment,the total efficacy of observation group (93.75) was higher than that of control group (59.38%),the difference was statistically significant (P0.05).Conclusion Tandospirone combined escitalopram in obsessive-compulsive disorder can relief the obsession ,anx-iety symptoms,safe and effective ,and not increase the risk of adverse reactions .