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目的探讨株洲地区女性人乳头瘤病毒(HPV)感染及其亚型分布状况,为HPV感染和宫颈癌的防治提供理论依据。方法采用核酸分子导流杂交法检测株洲地区2009年1月-2010年1月2 186例女性门诊患者HPV DNA,并对其亚型感染分布情况进行比较。结果株洲地区2 186例女性患者共检出HPV阳性902例,阳性率为41.26%(902/2 186),21种亚型均被检出。902例阳性样本中,HPV单一感染者587例,占65.08%(587/902);多重感染者314例,以二重感染为主,269例,占多重感染总数的85.67%(269/314),此外还检测出1例比较罕见的九重感染病例(HPV6、16、39、42、51、52、58、66、CP8304)。结论调查人群HPV感染率具有一定的区域性,HPV-52、11型可能是株洲地区妇女较易感染的亚型,值得重视。
Objective To investigate the distribution of human papillomavirus (HPV) and its subtypes in Zhuzhou area, and to provide a theoretical basis for the prevention and treatment of HPV infection and cervical cancer. Methods HPV DNA of 2 186 female outpatients from January 2009 to January 2010 in Zhuzhou area were detected by flow cytometry. The distribution of subtype infection was compared. Results A total of 902 HPV positive cases were detected in 2 186 female patients in Zhuzhou area, with a positive rate of 41.26% (902/2 186). All 21 subtypes were detected. Of the 902 positive samples, 587 were HPV single infection, accounting for 65.08% (587/902); multiple infection was 314, of which 269 were double infection, accounting for 85.67% (269/314) of the total number of multiple infections In addition, a rare case of nine-fold infection was detected (HPV6, 16, 39, 42, 51, 52, 58, 66, CP8304). Conclusion The prevalence of HPV infection in the survey population is of a certain regional nature. HPV-52 and 11 may be the more vulnerable subtype in Zhuzhou area, which deserves attention.