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目的使用COX-2抑制剂塞来昔布和传统NSAIDS双氯芬酸;观察对患者止痛效果和胃肠道安全的影响。方法选择骨关节炎(OA)患者120例,分为两组。一组使用传统NSAIDS双氯芬酸,一组使用COX-2抑制剂塞来昔布胶囊,两组用药分阶段至半年评估对胃肠道耐受性影响。结果NSAIDS组胃肠道不耐受性半年停药80%,塞来昔布组胃肠道不耐受性半年停药只占38%。两组止痛效果相当。结论COX-2抑制剂塞来昔布用于骨关节炎治疗止痛效果满意,胃肠道安全性好。
Objective To investigate the effect of COX-2 inhibitor celecoxib and traditional NSAID diclofenac on analgesia and gastrointestinal safety in patients. Methods A total of 120 patients with osteoarthritis (OA) were divided into two groups. One group used traditional NSAIDS diclofenac, one group received celecoxib, a COX-2 inhibitor, and the two groups evaluated the effects on gastrointestinal tolerance in phases to six months. Results In the NSAIDS group, gastrointestinal intolerance was discontinued for 80% of the six months, and celecoxib was only 38% of the gastrointestinal intolerance for six months. The two groups had similar analgesic effects. Conclusion The COX-2 inhibitor celecoxib is effective in the treatment of osteoarthritis and has good gastrointestinal tract safety.