论文部分内容阅读
巯甲丙脯氨酸(Captopril)其化学结构为D-3-巯基-2-甲基丙酰-L-脯氨酸。是血管紧张素Ⅰ转化酶的抑制剂,使血管紧张素Ⅰ不能转变为血管紧张素Ⅱ。口服1—20毫克,即可抑制由于静点血管紧张素Ⅰ所引起的升压作用。此外,血管紧张素转化酶也是缓激肽酶,它同时可使组织内的激肽迅速失活。我们知道。缓激肽具有舒张血管的作用。因此巯甲丙脯氨酸抑制了缓激肽酶,可使缓激肽血浓度增高,使血管舒张作用加强。前一种作用是大家公认的降压机制,后者仍有争论,但多数人认为这是该药降压作用的另一机制。
Captopril has a chemical structure of D-3-mercapto-2-methylpropionyl-L-proline. Is an inhibitor of angiotensin I converting enzyme that renders angiotensin I unable to convert to angiotensin II. Oral 1-20 mg, you can inhibit the point of the angiotensin-induced hypertension caused by the role. In addition, angiotensin-converting enzyme is also a bradykinin enzyme that simultaneously inactivates the kinin in the tissue at the same time. we know. Bradykinin has the effect of relaxing blood vessels. Therefore, captopril proline inhibition of bradykinin, bradykinin can make the blood concentration increased, so that the role of vasodilation to strengthen. The former is well known as the antihypertensive mechanism, the latter is still controversial, but most people think this is another mechanism of antihypertensive effect of the drug.