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本文报告对542例癫痫病人进行抗病药毒副反应的前瞻性研究结果。在抗痫治疗的10年中，有95例（17.53％）病人出现不同的毒副反应。其中，苯妥英的毒副反应发生率为46.57％、卡马西平的发生率为9.62％、丙戌酸为7.10％、苯巴比妥为9.62％。毒副反应中最常见的是皮诊、共济失调、眼球震颤及胃肠道症状。有3例病人出现明显肝功能损伤。本文还讨论了毒副反应的发生规律及其对策。
This paper reports 542 cases of epilepsy patients resistant to toxic side effects of prospective studies. In the 10 years of anti-epilepsy treatment, 95 patients (17.53%) showed different side effects. Among them, the incidence of side effects of phenytoin was 46.57%, carbamazepine was 9.62%, propoxuric acid was 7.10% and phenobarbital was 9.62%. Toxicity is the most common clinical examination, ataxia, nystagmus and gastrointestinal symptoms. 3 patients showed significant liver damage. This article also discusses the occurrence of toxic and side reactions and its countermeasures.