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原发性免疫缺陷病(PID)是影响儿童生命健康的重要疾病,主要治疗策略是免疫重建或替代治疗。近年来,随着分子诊断技术的发展,多种PID致病机制得以明确。在此基础上,针对免疫受损位点的靶向治疗逐渐在临床开展,并取得一定效果。文章就目前成熟的用于PID的靶向治疗做一阐述。
Primary immune deficiency disease (PID) is an important disease affecting children’s life and health, the main treatment strategy is immune reconstruction or replacement therapy. In recent years, with the development of molecular diagnostic techniques, a variety of PID pathogenesis to be clear. On this basis, the targeting of immune compromised sites gradually carried out in clinical practice, and achieved some results. The article is a well-established targeted therapy for PID.