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目的:探讨免疫PCR检测的预测应用,检测血管内皮生长因子-C(VEGF-C)的表达水平及意义,以及乳腺癌患者生存质量的主要影响因素并总结研究方法。方法:本院2007-05/2010-04收治的136例乳腺癌患者(实验组)的临床资料进行了回溯式分析并总结研究,并与同期收治的132例乳腺良性肿瘤患者(对照组)的生存质量进行比较。结果:两组患者血清p185蛋白的免疫检测发现,p185蛋白阳性表达对乳腺癌的临床诊断及预后存在统计学意义。血清p185阳性患者80.5%可发生复发或转移,显著高于阴性组的12.5%(P<0.05)。实验组患者术前血清VEGF-C的水平显著高于对照组患者(P<0.05),但治疗1个月后对照组VEGF-C的水平较治疗前有显著降低(P<0.05)。结论:检测血清P185蛋白以及VEGF-C的水平对于乳腺癌患者的诊断、治疗及预后判断均有显著的重要意义。p185蛋白阳性患者易复发,且VEGF-C的水平术后降低越多者治疗效果越显著,生存质量越好。
OBJECTIVE: To investigate the predictive value of immuno-PCR in detecting the expression of vascular endothelial growth factor-C (VEGF-C) and its significance, as well as the main influencing factors of the quality of life in patients with breast cancer and to summarize the research methods. Methods: The clinical data of 136 patients with breast cancer (experimental group) treated in our hospital from May 2007 to April 2010 were retrospectively analyzed and compared with 132 patients with benign breast tumors (control group) The quality of life is compared. Results: Immunohistochemical detection of serum p185 protein in two groups of patients showed that the positive expression of p185 protein had statistical significance in the clinical diagnosis and prognosis of breast cancer. Serum p185 positive patients 80.5% recurrence or metastasis, significantly higher than the negative group of 12.5% (P <0.05). The level of VEGF-C in the experimental group was significantly higher than that in the control group (P <0.05), but the level of VEGF-C in the control group was significantly lower than that before treatment (P <0.05) after one month. Conclusion: The detection of serum P185 protein and VEGF-C levels are of great significance for the diagnosis, treatment and prognosis of patients with breast cancer. Patients with p185 protein positive relapse, and the more the level of VEGF-C decreased after surgery, the more significant the treatment effect, the better the quality of life.