Some recent experimental and theoretical work on spin-dependent electron-atom and electron-molecule collisions is reviewed. The spin is involved in such collisions by explicit spin-dependent interactions such as the spin-orbit interaction of the continuum electron (Mott scattering) but also by exchange, which, in conjunction with the Pauli principle, gives rise to observable spin exchange effects. We present results for Mn and Na atoms and experiments in which electron dichroism with chiral molecules has been studied.