肾素-血管紧张素系统(RAS)与多种疾病相关。作为RAS的最终效应途径,血管紧张素II起到了关键作用。本文综述了能够影响其合成及作用的主要途径:血管紧张素II受体拮抗剂(ARB)、糜酶(chymase)抑制剂和晚近发现的ACE2类物质及其相关研究。 The renin-angiotensin system (RAS) is associated with a variety of diseases. Angiotensin II plays a key role as the ultimate effector of RAS. This review summarizes the major pathways that can influence their synthesis and their role: angiotensin II receptor antagonists (ARBs), chymase inhibitors and recently discovered ACE2-like substances and their related studies.