论文部分内容阅读
为探讨甲状腺球蛋白(Tg)基因活性的改变对甲状腺疾病临床诊断的价值,对330例甲状腺病变者的 Tg 含量及其基因位点变异进行了研究。包括甲状腺癌30例(~(131)I 治疗21例,手术治疗9例),桥本甲状腺炎89例(甲状腺功能正常59例,甲状腺功能减低30例),甲亢211例(未治疗40例,抗甲状腺药物治疗中130例,~(131)I 治疗后41例)。结果:330例甲状腺疾病患者 Tg 基因位点脆性表达频率皆有不同程度的改变,无着丝粒断片和微核率明显增高。经~(131)I 治疗的21例甲状腺癌和41例甲亢病人,Fra8q22明显高于未经~(131)I 治疗的甲状腺癌和甲亢病人(t=7.349,P<0.01)。结论:~(131)I 辐射导致基因结构的损伤,8q22是受损伤的敏感位点。
To investigate the value of thyroglobulin (Tg) gene activity in the clinical diagnosis of thyroid disease, we studied the Tg content and genetic locus variation of 330 thyroid lesions. Including thyroid cancer in 30 cases (~ (131) I treatment in 21 cases, surgical treatment in 9 cases), Hashimoto thyroiditis in 89 cases (normal thyroid function in 59 cases, hypothyroidism in 30 cases), hyperthyroidism in 211 cases (40 cases without treatment, Thyroid drugs in the treatment of 130 cases, ~ (131) I after treatment in 41 cases). Results: The friability frequency of Tg gene locus in 330 cases of thyroid diseases varied with different degrees, and the number of non-centromere fragments and micronuclei were significantly increased. In 21 thyroid carcinomas and 41 hyperthyroidism patients treated with ~ (131) I, Fra8q22 was significantly higher than those without thyroid cancer and hyperthyroidism (t = 7.349, P <0.01). CONCLUSION: ~ (131) I radiation causes damage to gene structure, and 8q22 is a sensitive site for injury.