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目的:对比厄贝沙坦联合氨氯地平治疗老年糖尿病伴高血压患者的临床疗效。方法:选取我院2016年1月至2017年1月期间收治的90例老年糖尿病伴高血压患者,随机分为A组、B组和C组,各30例,其中A组单用厄贝沙坦进行治疗,B组予以氨氯地平治疗,C组则采用厄贝沙坦联合氨氯地平用药方案治疗。分别对三组的临床疗效,不良反应,治疗前后血压和血糖相关指标,血脂水平,以及脂联素、TNF-α、Hs-CRP等进行比较。结果:A组、B组和C组的临床总有效率分别为73.33%、80.00%和93.33%,差异显著(P<0.05);C组患者治疗后的血压、血糖和血脂相关指标明显优于其他两组和治疗前(P<0.05),其中B组治疗后稍高于C组,但两组差异不明显著(P>0.05);三组患者治疗后较治疗前的脂联素、TNF-α、Hs-CRP水平明显下降,其中以C组下降水平最为明显,差异显著(P<0.05);三组患者的药物不良反应比较无统计学差异(P>0.05)。结论:厄贝沙坦联合氨氯地平治疗老年糖尿病伴高血压患者临床疗效确切,可将患者的血糖和血压水平控制在较为正常的水平,且有效抑制了患者的炎症反应,值得推广。
Objective: To compare the clinical efficacy of irbesartan and amlodipine in the treatment of elderly patients with diabetes mellitus and hypertension. Methods: A total of 90 elderly patients with diabetes mellitus admitted to our hospital from January 2016 to January 2017 were randomly divided into A group, B group and C group, with 30 cases in each group. A group Tan for treatment, B group to be treated with amlodipine, C group is treated with irbesartan combined with amlodipine medication. The clinical efficacy, adverse reactions, blood pressure and blood glucose-related indicators, blood lipid levels, adiponectin, TNF-α, Hs-CRP, etc. were compared between the three groups. Results: The total clinical effective rates of group A, group B and group C were 73.33%, 80.00% and 93.33%, respectively (P <0.05). The blood pressure, blood glucose and blood lipids in group C were significantly better than those of group C (P <0.05). The B group was slightly higher than C group after treatment, but there was no significant difference between the two groups (P> 0.05). The levels of adiponectin, TNF- α, Hs-CRP levels decreased significantly, of which the most significant decline in C group, the difference was significant (P <0.05); three groups of patients with adverse drug reaction was no significant difference (P> 0.05). CONCLUSION: Irbesartan combined with amlodipine has a definite curative effect in the treatment of elderly patients with diabetes mellitus and hypertension, which can control the blood sugar and blood pressure of the patients at a more normal level and effectively suppress the inflammatory reaction of the patients, which is worthy of popularization.