目前基因治疗骨肉瘤已取得了一定程度上的进展。现就功能性p53蛋白的导入、p53蛋白衍生物、细胞因子基因、自杀基因、骨钙蛋白启动子的应用等一系列研究在骨肉瘤的基因治疗实验中取得的疗效加以综述 ,尤其是应用Ad OC Ela(OCaP1)在对肺转移骨肉瘤的治疗已经到了临床实验的阶段 At present, gene therapy for osteosarcoma has made some progress. The introduction of functional p53 protein, p53 protein derivatives, cytokine genes, suicide genes, osteocalcin promoter and a series of studies in the treatment of osteosarcoma gene therapy to be reviewed, especially the application of Ad OC Ela (OCaP1) has been in clinical trials for the treatment of lung metastatic osteosarcoma