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经口给予雄性Ｗｉｓｔｅｒ大鼠醋酸铅２２ｍ ｇ／ｋｇ、乙醇１．８ｇ／ｋｇ 及铅和乙醇混合染毒４ 周。电镜观察睾丸显示，铅组、乙醇组基膜电子密度、厚度均发生明显改变，混合染毒除以上改变外，基膜及基膜下组织增厚，高度皱褶，甚至断裂。铅组支持细胞细胞器模糊，线粒体不完整；乙醇组支持细胞内溶酶体较多；混合染毒组支持细胞、精原细胞的胞质内多见大空泡；核帽期精细胞顶体短小，顶体颗粒消失，线粒体空化；精子断面拖有过多且有空泡的胞质，顶体帽短小不对称；间质细胞溶酶体、大的脂滴明显增多，滑面内质网、高尔基复合体、线粒体明显减少，表明铅和乙醇对大鼠睾丸的超微结构有联合增毒作用
Male Wistar rats were orally administered with 22 m g / kg lead acetate, 1.8 g / kg ethanol, and lead and ethanol for 4 weeks. Electron microscope observation of testis showed that the electronic density and thickness of basement membrane of lead group and ethanol group changed obviously. The mixed basement membrane and basement membrane were thickened, highly ruffled and even ruptured. Lead group support cell organelles fuzzy, mitochondria incomplete; ethanol group supporting cells more lysosomes; mixed exposure group of supporting cells, spermatogonia more cytoplasm large vacuoles; nucleocapsid sperm acrosome short, Acrosomal particles disappear, mitochondria cavitation; sperm section dragged too much and have vacuolar cytoplasm, acrosomal cap short asymmetry; interstitial cell lysosomes, large lipid droplets increased significantly, sliding surface endoplasmic reticulum, Golgi complex, mitochondria was significantly reduced, indicating that lead and ethanol on the ultrastructure of the rat testicles have a joint toxic effects