论文部分内容阅读
目的探讨肌萎缩侧索硬化(ALS)患者血清肌酸激酶(CK)的水平,及其与年龄、性别、病情分级、起病方式、病程之间的关系。方法回顾性分析40例确诊ALS并行血CK检查患者的临床资料,根据性别、年龄、起病部位、病情分级、病程进行分组,统计各组间CK水平的差异。结果本组患者CK为25～562U/L,平均88U/L。15例CK轻度增高。男女性别间CK水平差异无统计学意义(P=0.12),中青年组(<60岁)和老年组(≥60岁)CK水平差异无统计学意义(P=0.85),临床分级轻度、中度、重度、危重组间CK水平差异无统计学意义(P=0.58),病程较短组(<1年)和较长组(≥1年)CK水平差异无统计学意义(P=0.11);球部起病组CK水平明显低于肢体起病组[(109.54±23.40)U/Lvs.(206.13±29.56)U/L,P=0.02]。结论 CK增高在ALS患者中并不少见,肢体起病者CK水平更高,CK水平与年龄、性别、病程、病情分级不相关。
Objective To investigate the serum creatine kinase (CK) level in patients with amyotrophic lateral sclerosis (ALS) and its relationship with age, sex, grading, onset and duration of disease. Methods The clinical data of 40 patients diagnosed with concurrent ALS by ALS were retrospectively analyzed. The differences of CK levels among groups were statistically analyzed according to gender, age, onset site, disease grade and course of disease. Results The patients CK was 25 ~ 562U / L, with an average of 88U / L. 15 cases of mild increase in CK. There was no significant difference in CK levels between men and women (P = 0.12), no significant difference in CK levels between young and middle-aged patients (<60 years old) and elderly patients (≥60 years old) There was no significant difference in CK levels between the moderate, severe and critically ill groups (P = 0.58), no significant difference in the CK levels between the shorter course (<1 year) and the longer group (≥ 1 year) (P = 0.11 ). The CK level in the dome group was significantly lower than that in the limb onset group [(109.54 ± 23.40) U / L vs (206.13 ± 29.56) U / L, P = 0.02]. Conclusions CK is not uncommon in patients with ALS. CK levels are higher in patients with limb onset, and CK level is not related to age, sex, course of disease and grade of disease.