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目的观察一株蝉拟青霉菌种培养物的经口动物毒性。方法将蝉拟青霉菌种分别接种于马铃薯-酵母膏-蔗糖、麦芽汁-蛋白胨及麦芽汁-酵母膏3种不同的产毒培养基,培养14d后,使用其培养物原液及2.5倍浓缩液,经口一次性灌胃给予ICR小鼠,雌雄各半,并随后连续观察14d中小鼠的中毒表现及死亡情况。结果其培养物对实验动物未见有毒性反应或死亡。结论初步证明了蝉拟青霉的安全性。
Objective To observe the oral toxicity of a culture of Paecilomyces cicadae. Methods Cicloptilon citrinum was inoculated into three kinds of toxin-producing medium of potato-yeast extract-sucrose, wort-peptone and wort-yeast extract separately. After cultured for 14 days, the culture solution and 2.5 times concentrated solution , Once a single intragastric administration of ICR mice, male and female, and then continuous observation 14d mice poisoning performance and death. As a result, no toxicity or death of the culture was observed in the test animals. Conclusion The safety of cicadae Penicillium was initially proved.