论文部分内容阅读
目的评价胃癌术后口服沙培林对胃癌远期疗效的影响。方法152例符合条件的胃癌手术后患者随机分为两组,单纯化疗组(对照组)75例,化疗加沙培林组(观察组)77例。对照组采用标准DF方案,观察组用DF方案加口服沙培林,进行前瞻性对比观察和为期5年的远期疗效评价。结果两组的毒性反应差异无显著性。远期疗效1,2,3,5的生存率观察组分别为84.4%(65/77)、75.3%(56/77)、67.5%(52/77)和61.0%(47/77);对照组分别为82.7%(62/75)、61.3%(46/75)、50.7%(38/75)和46.7%(35/65)。两组比较2,3,5年生存率差异均有显著性(P<0.05)。结论胃癌术后口服沙培林具有较好的耐受性和安全性,毒副作用无增加,主要仍表现为化疗药物的毒副作用,其远期疗效优于单纯化疗组。
Objective To evaluate the long-term effect of oral administration of saponin on gastric cancer after gastric cancer surgery. Methods A total of 152 eligible gastric cancer patients were randomly divided into two groups: 75 in the chemotherapy alone group and 77 in the Gazaprine group. The control group with standard DF program, the observation group with oral solution plus sappaphir, for prospective comparative observation and 5-year long-term efficacy evaluation. Results There was no significant difference in toxicity between the two groups. Survival rates of long-term efficacy 1,2,3,5 were 84.4% (65/77), 75.3% (56/77), 67.5% (52/77) and 61.0% (47/77), respectively Groups were 82.7% (62/75), 61.3% (46/75), 50.7% (38/75) and 46.7% (35/65), respectively. The difference of 2, 3, 5-year survival rates between the two groups was significant (P <0.05). Conclusions Oral sAP after gastric cancer treatment has better tolerability and safety, with no increase in toxic and side effects, mainly showing the toxic side effects of chemotherapy drugs. Its long-term efficacy is better than that of chemotherapy alone group.