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目的：探讨~(125)Ⅰ种子源术中植入是否能进一步提高进展期中下段直肠癌的治疗效果。方法：对78例中下段直肠癌手术根治患者(均为Dukes B或C期),分成3组：A组(手术根治加化疗组)28例；B组(手术根治加放疗组)18例；C组(手术根治联合~(125)Ⅰ种子源植入组)28例；跟踪随访观察2年内的复发率；同时比较B组与C组的并发症发生情况。结果：显示3组1年半内复发率分别为46%、13．6%、14．2%；B组和C组复发率均低于A组(P＜0．05),C组复发率与B组无显著差异；但C组并发症的发生率(10．7%)比B组(40．9%)明显降低(P＜0．05)。结论：~(125)Ⅰ放射性种子源术中植入有助于预防直肠癌术后的复发,与体外放疗效果相仿,并且并发症的发生率低,比后者更安全。
Objective: To investigate whether the implantation of ~ (125) Ⅰ seeds could further improve the therapeutic effect of advanced stage lower rectal cancer. Methods: A total of 78 patients with radical resection of rectal cancer underwent radical surgery (Dukes B or C). The patients were divided into three groups: group A (radical mastectomy plus chemotherapy group); group B (radical mastectomy plus radiotherapy group) C group (radical cane combined with (125) Ⅰ seed implantation group) 28 cases were followed up for 2 years. The incidence of complications in group B and group C were also compared. Results: The recurrence rates in one and a half years in the three groups were 46%, 13.6% and 14.2%, respectively. The recurrence rates in group B and C were lower than those in group A (P <0.05) There was no significant difference between group B and group B (P <0.05), but the complication rate in group C (10.7%) was significantly lower than that in group B (40.9%) (P <0.05). CONCLUSION: The implantation of ~ (125) Ⅰ radioactive seeds can help prevent postoperative recurrence of rectal cancer, which is similar to the effect of radiotherapy in vitro. The incidence of complications is lower and safer than the latter.