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目的对老年人群进行认知功能评定,探讨代谢异常因素对认知功能的影响,为老年痴呆的早防、早治提供依据。方法选择老年人群2315例,根据简易智能状态检查量表(MMSE),分为MMSE正常组(2283例)和MMSE异常组(32例),进行流行病学调查,检测身高、体重、腰臀围、血压、血脂、血糖等指标,并进行统计学分析。结果 MMSE异常组年龄、腰围、腰臀比、HDL-C、收缩压、空腹血糖明显高于MMSE正常组,差异有统计学意义(P<0.05)。中心性肥胖、超重或肥胖、HDL-C异常、高血压、空腹血糖升高人群MMSE评分明显低于对应正常人群,差异有统计学意义(P<0.05,P<0.01)。Pearson相关分析显示,体重指数、腰围、腰臀比、收缩压、空腹血糖与MMSE评分呈负相关,HDL-C与MMSE评分呈正相关。线性多元回归分析显示,MMSE评分与受教育程度、经济收入、吸烟、饮酒、年龄、腰围、收缩压、空腹血糖和HDL-C密切相关。结论老年人群的认知功能与年龄、受教育程度、吸烟及饮酒等密切相关,同时中心性肥胖、高血压、血脂异常及高血糖等代谢异常与认知功能障碍的受损程度亦密切相关。
Objective To evaluate the cognitive function of the elderly population and explore the influence of metabolic abnormalities on cognitive function to provide evidence for the prevention and early treatment of senile dementia. Methods A total of 2315 elderly patients were selected and divided into MMSE normal group (2283 cases) and MMSE abnormal group (32 cases) according to the Mini-Mental State Examination Scale (MDE) to carry out epidemiological investigation to detect the height, weight, , Blood pressure, blood lipids, blood glucose and other indicators, and statistical analysis. Results The age, waist circumference, waist-hip ratio, HDL-C, systolic blood pressure and fasting blood glucose of MMSE group were significantly higher than those of normal MMSE group (P <0.05). The MMSE scores of central obesity, overweight or obesity, HDL-C abnormalities, hypertension and fasting hyperglycemia were significantly lower than those of corresponding normal subjects (P <0.05, P <0.01). Pearson correlation analysis showed that body mass index, waist circumference, waist-hip ratio, systolic blood pressure, fasting blood glucose and MMSE score was negatively correlated, HDL-C and MMSE score was positively correlated. Linear multivariate regression analysis showed that MMSE score was closely related to education, income, smoking, drinking, age, waist circumference, systolic blood pressure, fasting blood glucose and HDL-C. Conclusion Cognitive function in the elderly is closely related to age, education level, smoking and alcohol consumption. At the same time, metabolic disorders such as central obesity, hypertension, dyslipidemia and hyperglycemia are closely related to the degree of impairment of cognitive impairment.