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目的探讨心脑血管患者血清甲状腺激素T3、T4、TSH的变化特点及临床意义。方法研究对象共分四组:冠心病组(39例)、慢性心衰组(41例)、脑梗塞组(42例)和健康人对照组(32例)。应用荧光磁微粒酶免疫分析法测定各组血清中T3、T4、TSH水平。结果心脑血管患者血清甲状腺激素T3水平明显低于健康人对照组(P<0.01),甲状腺激素T4、TSH与健康人对照组相比较无统计学差异(P>0.05),心脑血管病人间血清T3、T4、TSH水平均无明显差异(P>0.05)。结论心脑血管疾病存在血甲状腺激素分泌的异常。其可能在心脑血管疾病的发病机理中起重要作用,检测血清甲状腺激素T3、T4、TSH可作为反映心脑血管病人病情程度和评估预后的一项有益的参数。
Objective To investigate the changes and clinical significance of serum thyroid hormones T3, T4 and TSH in patients with cardiovascular and cerebrovascular diseases. Methods The subjects were divided into four groups: coronary heart disease (39 cases), chronic heart failure (41 cases), cerebral infarction (42 cases) and healthy control group (32 cases). The levels of T3, T4 and TSH in serum of each group were determined by fluorescence microgravity enzyme immunoassay. Results Serum thyroid hormone T3 levels in patients with cardiovascular and cerebrovascular diseases were significantly lower than those in healthy controls (P <0.01). There were no significant differences in thyroid hormone T4 and TSH between healthy controls and control subjects (P> 0.05) Serum T3, T4, TSH levels were no significant difference (P> 0.05). Conclusions Cardiac and cerebrovascular diseases have abnormalities of thyroid hormone secretion. It may play an important role in the pathogenesis of cardiovascular and cerebrovascular diseases. Detecting serum thyroid hormones T3, T4, TSH can be used as a useful parameter to reflect the severity of cardiovascular and cerebrovascular diseases and evaluate the prognosis.