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目的 探讨不同水平的高密度脂蛋白胆固醇 (HDL C)与老年男性患者心肌梗死、原发性高血压、糖尿病、脑血管疾病、慢性肾功能衰竭、恶性肿瘤及其他血脂指标的关系。 方法 1986～1998年 188例老年男性患者全部经尸检明确诊断 ,根据 6～ 13年间 (平均 10 2年 )连续每年体格检查取得的各项血脂平均值和临床资料 ,分为HDL C≤ 1 0 3mmol/L、HDL C 1 0 4～ 1 5 3mmol/L、HDL C≥ 1 5 4mmol/L 3组。观察其对各种疾病的影响。 结果 心肌梗死、糖尿病、肥胖和高甘油三酯血症的发生与HDL C水平降低明显有关 (P <0 0 1)。随着HDL C水平的升高 ,总胆固醇也随之增高 ,而甘油三酯、体重指数和总胆固醇 /HDL C比值均明显下降 (P <0 0 1)。总胆固醇随着年龄的增长有下降趋势。 结论 HDL C水平降低可能促进冠状动脉粥样硬化的发生和发展 ,使心肌梗死的患病率明显增高。老年人低HDL C水平不仅是心血管疾病的危险因素 ,可能还是揭示一些慢性疾病的指标
Objective To investigate the relationship between different levels of high density lipoprotein cholesterol (HDL C) and myocardial infarction, essential hypertension, diabetes mellitus, cerebrovascular disease, chronic renal failure, malignant tumor and other blood lipid in elderly male patients. Methods A total of 188 elderly male patients were diagnosed by autopsy from 1986 to 1998. According to the average of blood lipids and clinical data obtained from consecutive physical examinations in 6 to 13 years (on average 102 years), the patients were divided into HDL C≤130mmol / L, HDL C10 4 ~ 153 mmol / L, and HDL C ≥ 154 mmol / L 3 groups. Observe its impact on various diseases. Results The occurrence of myocardial infarction, diabetes, obesity and hypertriglyceridemia was significantly related to the decrease of HDL C level (P <0.01). With the increase of HDL C, total cholesterol also increased, but triglyceride, body mass index and total cholesterol / HDL C ratio decreased significantly (P <0.01). Total cholesterol with the growth of the declining trend. Conclusions The decrease of HDL C may promote the occurrence and development of coronary atherosclerosis, and the prevalence of myocardial infarction is significantly higher. Low HDL C in the elderly is not only a risk factor for cardiovascular disease but may also reveal some indicators of chronic disease