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目的研究纤维蛋白原(fibrinogen,Fg)浓度、分子聚合功能及FgBβ-148、448基因多态性与脑梗塞类型的关系。方法采用病例对照研究,应用聚合酶链反应-限制性酶切法进行基因多态性分析,并测定血浆Fg浓度及其分子聚合功能参数。结果FgBβ-148变异基因型人群脑动脉主干支梗塞组血浆Fg浓度高于脑动脉穿通支梗塞组及对照组;448变异基因人群脑动脉主干支梗塞组Fg浓度、纤维蛋白单体聚合速率/最大吸光度、纤维蛋白单体聚合速率高于对照组,Fg浓度高于脑动脉穿通支梗塞组。结论FgBβ-148、448基因型发生变异后可通过影响Fg浓度而使此人群发生脑动脉主干支梗塞组的危险性升高。
Objective To investigate the relationship between fibrinogen (Fg) concentration, molecular polymerization and FgBβ-148,448 polymorphisms and cerebral infarction types. Methods A case-control study was conducted. The gene polymorphism was analyzed by polymerase chain reaction-restriction enzyme digestion, and the plasma Fg concentration and functional parameters of its molecular polymerization were determined. Results The Fg concentration in the main artery infarction group was higher than that in the cerebral artery perfusion branch infarction group and the control group in the FgBβ-148 variant genotype population. The Fg concentration and fibrin monomer polymerization rate in the 448 variant group Absorbance, fibrin monomer polymerization rate higher than the control group, Fg concentration higher than the cerebral artery perforating branch infarction group. Conclusion The mutation of FgBβ-148,448 genotype may increase the risk of developing cerebral artery occlusion in this population by affecting the Fg concentration.