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目的:对比分析米索前列醇通过不同给药途径下预防剖宫产术出血的疗效情况。方法:将我院2012年1月~2013年6月期间收治的有产后出血高危因素的90例需剖宫产的孕妇随机分为3组,即A组30例,B组30例,C组30例。3组产妇均行腰硬联合麻醉下剖宫产术,在米索前列醇给药途径上A组行宫内给药,B组行口服给药,C组行直肠给药。计算并统计3组产妇术中、术后2h出血量及产妇用药后不良反应的发生率。结果:A组产妇的术中平均出血量少于B组和C组(P<0.05),在术后2h出血量上,3组比较,差异无统计学意义(P﹥0.05)。用药后,A组未发生任何不良反应,B组不良反应发生率为16.67%(5/30),C组为10%(3/30),A组产妇用药后不良反应发生率明显低于B组和C组(P<0.05)。结论:米索前列醇宫内给药是预防剖宫产术出血最有效、最安全的方法,值得临床推广与应用。
Objective: To compare and analyze the curative effect of misoprostol on prevention of bleeding after cesarean section by different routes of administration. Methods: Ninety pregnant women undergoing cesarean section with high risk factors for postpartum hemorrhage admitted to our hospital from January 2012 to June 2013 were randomly divided into 3 groups: 30 cases in group A, 30 cases in group B and 30 cases in group C 30 cases. Three groups of women underwent cesarean section under spinal and epidural anesthesia. Group A received intrauterine administration in misoprostol administration group, Group B received oral administration and group C received rectal administration. Calculation and statistics of 3 groups of maternal surgery, 2h postoperative bleeding and the incidence of adverse reactions after maternal medication. Results: The average intraoperative blood loss in group A was less than that in group B and C (P <0.05). There was no significant difference in the amount of bleeding 2h after operation between the three groups (P> 0.05). After treatment, there was no adverse reaction in group A, the incidence of adverse reactions in group B was 16.67% (5/30), and that in group C was 10% (3/30). The incidence of adverse reactions in group A was significantly lower than that in group B Group and C group (P <0.05). Conclusion: Intrauterine administration of misoprostol is the most effective and safest method to prevent bleeding after cesarean section, which is worthy of clinical application and promotion.