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目的 :探讨鼻咽癌患者放疗前后血清中血管内皮生长因子 (VEGF)的变化及临床意义。方法 :应用酶联免疫吸附法 (ELISA)对 4 6例鼻咽癌患者放疗前后血清中VEGF水平进行检测。结果 :鼻咽癌患者放疗前血清VEGF水平明显高于正常人 (P <0 .0 1) ,并随病情进展而升高 ;放疗后VEGF水平较放疗前明显降低 (P <0 .0 1)。VEGF水平 >15 0ng/L与 <15 0ng/L者的复发或转移率有明显差异 (P <0 .0 1)。结论 :VEGF不仅与鼻咽癌发生、发展有关 ,而且与其预后也密切相关 ,可望作为鼻咽癌患者预后的一个新的检测指标
Objective: To investigate the changes of serum vascular endothelial growth factor (VEGF) in patients with nasopharyngeal carcinoma before and after radiotherapy and its clinical significance. Methods: Serum levels of VEGF in 46 patients with nasopharyngeal carcinoma (NPC) before and after radiotherapy were detected by enzyme-linked immunosorbent assay (ELISA). Results: The serum level of VEGF in patients with nasopharyngeal carcinoma before radiotherapy was significantly higher than that in normal people (P <0.01), and increased with the progression of the disease. The level of VEGF in radiotherapy was significantly lower than that before radiotherapy (P <0.01) . The recurrence or metastasis rate of patients with VEGF> 150ng / L and <150ng / L was significantly different (P <0.01). Conclusion: VEGF is not only associated with the occurrence and development of nasopharyngeal carcinoma, but also with its prognosis, which is expected to be a new detection index for the prognosis of patients with nasopharyngeal carcinoma