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空卵泡综合征最初是指在体外受精(IVF)周期未能取到卵母细胞,一般发生率为2％～7％。这样的妇女在下一周期中是否还会出现这种综合征,目前仍有争议。出现该综合征的原因还不十分明确,有人认为与导致妇女不孕的原因有关,而另一些人认为可能与使用促卵泡生长的药物有关。 Tsuiri等报道1例空卵泡综合征妇女曾行2个周期IVF,均受孕失败。他们认为是由于该患者生殖功能的内在缺陷所致,也可能是早期卵泡闭锁,而卵泡经刺激后仍可产生明显的正常激素反应。 然而,Zegers-Hochschild等提供证据显示,空卵泡综合征是某些药品商应用人绒毛膜促性腺激素(hCG)生物活性在体内异常作用所致。他们认为空卵泡综合征的卵泡液内分泌不正常不是卵巢本身异常的结果,而是因为缺乏有生物活性的hCG的刺激。
Follicular syndrome initially means that oocytes can not be obtained during in vitro fertilization (IVF) cycles, with a general incidence of 2% to 7%. It is still debatable whether such women will develop the syndrome in the next cycle. The cause of the syndrome is not well understood, and some believe it is related to the causes of infertility in women, while others think it may be related to the use of follicle-stimulating drugs. Tsuiri et al reported a case of empty follicle syndrome women had two cycles of IVF, have failed to conceive. They think it is due to the patient’s inherent defects in reproductive function may also be early follicular atresia, and the follicle can still produce significant stimulation of normal hormone response. However, Zegers-Hochschild et al. Provide evidence that empty follicular syndrome is an abnormal effect of some pharmaceutical manufacturers applying human chorionic gonadotropin (hCG) bioactivity in vivo. They think the follicular fluid of empty follicular syndrome is not abnormal endocrine results of abnormal ovarian itself, but because of the lack of biologically active hCG stimulation.