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目的 :探讨奥卡西平(OXC)与卡马西平(CBZ)对成人部分性癫患者睡眠结构和呼吸事件的影响.方法 :对单用OXC的成人癫患者26例进行多项睡眠图(PSG)检查,同步行长程视频脑电图(V-EEG)检查,与单用CBZ的患者进行比较,并与健康对照组比较,分析各组睡眠结构和呼吸事件改变情况.结果 :单用OXC的患者与健康对照组相比,表现为REM潜伏期增加,REM期减少,NREMⅠ期睡眠增加,NREMⅡ期睡眠减少,睡眠效率降低,NREMⅢ-Ⅳ期睡眠增加,周期性腿动指数增加.与单用CBZ组相比,两者无显著差异.结论 :单用OXC的成人癫患者存在睡眠结构紊乱,其对睡眠结构和睡眠呼吸事件的影响与CBZ相仿,对癫患者的睡眠影响相对有利.“,”Objective:To observe the effect of oxcarbazepine and carbamazepine on sleep structure and sleep apnea events in patients with epilepsy .Methods :Twenty-six patients with epilepsy who took oxcarbazepine underwent examinations of video-polysomnogragphy (PSG) and long-term video EEG (V-EEG) .The changes of sleep structure and sleep apnea events were analyzed and compared with those in patients who took carbamazepine and those in the healthy controls .Results:Compared with the healthy controls ,the oxcarbazepine group was found to have longer rapid eye movement (REM ) in sleep latency , shorter REM stage ,higher percentage of non-rapid eye movement Ⅰ (NREM Ⅰ ) and NREM Ⅲ - Ⅳ , lower percentage of NREM Ⅱ ,lower sleep emciency .Meanwhile ,the periodic limb movement(PLM) in-dex increased .There was no significant difference between the oxcarbazepine group and the carbamaz-epine group .Conclusion:Oxcarbazepine can alter sleep structure of adult patients with epilepsy . The effect is desirable and similar to carbamazepine on sleep structure and sleep apnea events .