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去年十一月二日,美国Riggs和Boyer等七人研究小组报告用化学方法合成的生长激素释放制抑因子(Somatostatin,以下缩写为som)的基因,已通过遗传工程技术重组,转移到大肠杆菌中,并且从这细菌的发酵液成功地获得了期望的脑激素——som,第一次用合成的基因创造了能生产脑激素的大肠杆菌。美国科学院院长Handler欢呼这是“科学上头等的大胜利”。在此以前,虽已有大量基因转移到大肠杆菌中,但是却没有一个能生产预先设计的蛋白质或多肽,例如去年夏天加州大学重组DNA的胰岛素小组报导:大鼠胰岛素基因转移进大肠杆菌已获得成功,但用此细菌生产胰岛素却没有成功。
On November 2 last year, a team of seven researchers such as Riggs and Boyer from the United States reported that the chemically synthesized somatostatin gene (som), which has been chemically synthesized, has been genetically engineered to transfer into Escherichia coli , And successfully obtained the desired brain hormone-som from this bacterial fermentation broth, for the first time using synthetic genes to create E. coli capable of producing brain hormones. Handler, dean of the American Academy of Sciences, hails this as “a great scientific victory.” Prior to this, although a large number of genes have been translocated to E. coli, none have been able to produce pre-engineered proteins or peptides. For example, the insulin panel at the University of California last summer reported that rat insulin gene transfer into E. coli has been obtained Success, but using this bacteria to produce insulin has not been successful.