论文部分内容阅读
阿斯匹林自1899年问世以来,临床应用已80余年,至今仍广泛用于解热、镇痛、抗风湿,还可用于驱除胆道蛔虫和抑制血小板凝聚。产量逐年增加,目前世界年产量已超过4万吨。由于本品在水中溶解度很低和遇水极易分解,因此只能供口服用。而口服阿斯匹林如长期和大剂量应用可引起胃肠道出血和溃疡症。为此,国内外一些药厂将其制成钙盐、铝盐或肠溶衣片、缓冲双层片、栓剂、微
Since its publication in 1899, aspirin has been used clinically for over 80 years and is still widely used in antipyretic, analgesic and anti-rheumatic diseases. It can also be used to expel biliary ascariasis and inhibit platelet aggregation. The output has been increasing year by year. At present, the annual output in the world has exceeded 40,000 tons. As this product is very low in water solubility and water easily decomposed, it can only be used orally. Oral aspirin, such as long-term and high-dose applications can cause gastrointestinal bleeding and ulcer disease. To this end, some domestic and foreign pharmaceutical companies will be made of calcium salt, aluminum salt or enteric coated tablets, double-layered buccal tablets, suppositories, micro