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目的探究25羟维生素D(25OH-D)的水平与结缔组织病相关肺间质病变(CTD-ILD)的相关性。方法选取2016年1月至12月我院收治的68例CTD-ILD患者,设为观察组,选取同期70名健康体检者作为对照组,采用酶联免疫法检测2组受检者血清25OH-D水平并进行对比,同时对25OH-D水平与体质量指数(BMI)、红细胞沉降率(ESR)、C反应蛋白(CRP)、类风湿因子(RF)、抗核抗体(ANA)、补体C3、C4、一氧化碳弥散量占比(DLCOSB)、1s率(FEV1/FVC)的相关性进行统计分析。结果观察组25OH-D平均为(25±4)ng/mL,显著低于对照组的(46±11)ng/mL,且观察组25OH-D缺乏率达到93%(63/68),显著高于对照组的6%(4/70),差异均有统计学意义(P<0.05);不同类型结缔组织病患者之间的25OH-D水平对比差异无统计学意义(P>0.05);CTD-ILD患者血清25OH-D水平与BMI、ESR、FEV1/FVC均呈负相关(P<0.05),与DLCOSB水平呈正相关(P<0.05),与其他因素无明显相关(P>0.05)。结论 CTD-ILD患者的血清25OH-D水平明显低于健康人群,且与患者BMI、ESR及肺功能有关,应当引起重视。
Objective To investigate the correlation between the level of 25OH-D and CTD-ILD in connective tissue diseases. Methods Sixty-eight patients with CTD-ILD admitted from January 2016 to December 2016 in our hospital were selected as the observation group. 70 healthy subjects were selected as the control group. The serum levels of 25OH- D levels were compared with those of 25OH-D. The levels of 25OH-D and body mass index (BMI), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), antinuclear antibody (ANA) , C4, carbon monoxide dispersion ratio (DLCOSB), 1s rate (FEV1 / FVC) were analyzed statistically. Results The 25OH-D in the observation group was (25 ± 4) ng / mL on average, significantly lower than that in the control group (46 ± 11) ng / mL, and the rate of 25OH-D deficiency in the observation group was 93% (63/68) (P <0.05). There was no significant difference in the level of 25OH-D between different types of patients with connective tissue disease (P> 0.05). Serum 25OH-D levels in patients with CTD-ILD were negatively correlated with BMI, ESR and FEV1 / FVC (P <0.05), but positively correlated with DLCOSB (P <0.05). Conclusions Serum 25OH-D level in patients with CTD-ILD is significantly lower than that in healthy people, and should be paid more attention to with BMI, ESR and pulmonary function.