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目的 :优选补肾健骨胶囊有效成分的工艺条件。方法 :利用均匀设计法安排试验 ,以熊果酸含量为指标成分进行评价 ,利用多元回归 ,确定最佳醇提工艺参数 ;用正交试验的方法 ,以干膏率和醇溶物为考核指标进行考察影响水煮的药材粒径、煎煮时间和用水量 3因素。结果 :最佳醇提的工艺条件为 :8倍量 70 %的乙醇渗漉 48h。最佳水煮提取工艺条件为 :药材粒径小于 1cm ,水煮 3次 ,分别为 3h、2h、1h ,加水量依次为 10倍、8倍和 6倍。结论 :利用最佳工艺条件能充分有效地提取药材中的有效成分。
Objective: To optimize the technological conditions of Bushen Jiangu capsule active ingredient. Methods: The uniform design method was used to arrange the experiment, the ursolic acid content was used as the index component to evaluate, and the optimum alcohol extraction process parameters were determined by multiple regression analysis. Using the orthogonal test method, To investigate the impact of boiled herbs particle size, boiling time and water consumption 3 factors. Results: The optimal conditions of alcohol extraction were as follows: 8 times the amount of 70% ethanol percolation 48h. The optimum conditions for boiling extraction were as follows: the particle size of the medicinal material was less than 1 cm and the boiling time was 3 times, respectively, 3h, 2h, 1h, followed by 10 times, 8 times and 6 times. Conclusion: The best technology conditions can be fully and effectively extract the active ingredients in medicinal herbs.