为制备家犬暴发性肝功能衰竭(FHF)模型,采用静脉注射含30％乙酰氨基酚的二氨基亚枫溶液0.6ml/kg和皮下注射含40％四氯化碳的橄榄油0.6ml/kg。第9小时重复给药,但剂量减半。结果其一般表现、生化检验、血浆氨基酸分析等均符合肝昏迷的表现,肝脏形成的以小叶为中心的大块肝坏死病变进一步明确为FHF的特征性病理变化。本法简便,使肝毒药物的用量大大减少,成功率为90％,形成FHF的平均时间为43.5小时。 In order to prepare fulminant hepatic failure (FHF) model in domestic dogs, intravenous injection of diamino-subfamily solution of 30% acetaminophen 0.6ml / kg and subcutaneous injection of 40% carbon tetrachloride 0.6ml / kg . The first 9 hours of repeated administration, but the dose by half. The results of its general performance, biochemical tests, plasma amino acid analysis, etc. are consistent with the performance of hepatic coma, the formation of the liver lobular lesion as the center of the liver necrosis further clarified for the FHF characteristic pathological changes. This method is simple, greatly reduced the amount of hepatotoxic drugs, the success rate was 90%, the average time to form FHF was 43.5 hours.