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食管静脉曲张破裂出血临床常见,病死率高达28-60%,传统采用血管加压素和气囊压迫控制出血疗效欠佳。人工合成的八肽生长抑素长效类似物奥曲肽半衰期长,副作用少。一年余用奥曲肽治疗33例肝硬化失代偿合并食管静脉曲张破裂出血病人,总止血率为84.8%,其中每日持续静滴0.4~0.6mg者与只静滴O.1~0.2mg者相比,前者止血率为100%,后者止血率为54.5%。
Esophageal variceal bleeding clinical common, the mortality rate as high as 28-60%, the traditional use of vasopressin and balloon oppression to control bleeding is not effective. Synthetic Octapeptide Somatostatin Long-acting analogue octreotide has a long half-life with few side effects. One year of extra octreotide treatment of 33 patients with decompensated cirrhosis and esophageal variceal bleeding patients, the total hemostasis rate was 84.8%, of which daily intravenous infusion of 0.4 ~ 0.6mg and only intravenous infusion of O. 1 ~ 0.2mg compared to the former hemostasis rate was 100%, the latter bleeding rate was 54.5%.