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目的探索不同方法提取水蛭的有效成分,创制新制剂水蛭注射液。方法本文以凝血时间为指标对不同的提取方法进行比较,采用t检验进行分析,选择最佳提取方案,尝试制备水蛭注射液。结果(1)不同方法制得的水蛭注射液均有抗凝血作用,从经济角度考虑,本文采用生理盐水提取水蛭有效成分。(2)水蛭比蚂蝗、柳叶蚂蝗含有更高的抗凝成分。结论选用水蛭为原材料,利用生理盐水提取水蛭有效成分,采用三冻三缓、过滤等步骤能制备水蛭注射液。
Objective To explore different methods to extract the active ingredients of leeches and to create a new preparation of leech injection. Methods In this paper, coagulation time as an indicator of different extraction methods were compared using t-test analysis, select the best extraction program, try to prepare leech injection. Results (1) The leech injection prepared by different methods has the anticoagulant effect. From the economic point of view, the effective components of leech were extracted with saline. (2) leeches than leeches, willow leeches contain higher anticoagulant ingredients. Conclusion Leech was selected as the raw material, and the effective components of leeches were extracted by using physiological saline. The leech injection was prepared by the steps of three freeze, three slow and filtration.