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为探讨腹腔内给药治疗对腹膜后淋巴结的影响，采用顺铂腹腔内小剂量短期重复给药方式，观察30例卵巢癌患者术前48小时腹腔内化疗（单次注药组，15例）及术前96小时，48小时腹腔内化疗（重复注药组，15例）后，腹膜后淋巴结，周围结缔组织及腹膜中顺铂的浓度。结果显示，单次注药组和重复注药组腹膜后淋巴结内药物浓度是周围结缔组织的2．06倍和1．91倍，差异有高度显著性（P＜0．005）。单次和重复往药组腹膜中顺铂浓度分别是淋巴结的4．14和2．5倍，差异有高度显著性（P＜0．005）。重复给药组髂、闭孔、腹主淋巴结药物浓度是单次给药组的2．27倍、2．75倍、2．54倍，差异也有高度显著性（P＜0．005）。光镜下可见，重复给药组淋巴结内转移的癌组织出现液化性坏死，单次给药组仅见淋巴结有反应性增生。提示，顺铂腹腔内小剂量短期重复给药，可达药物积累效应，从而产生高效低毒结果，有可能成为治疗卵巢癌淋巴结转移的方法之一。
In order to investigate the effect of intraperitoneal administration on retroperitoneal lymph nodes, 30 cases of ovarian cancer patients undergoing intraperitoneal chemotherapy (single injection group, 15 cases) were treated with low dose intraperitoneal short-term repeated administration of cisplatin, And cisplatin concentrations in retroperitoneal lymph nodes, surrounding connective tissue and peritoneum after intraperitoneal chemotherapy (repeated injection group, 15 cases) at 96 hours and 48 hours before operation. The results showed that the drug concentration in the retroperitoneal lymph nodes of single injection group and repeated infusion group was 2.06 times and 1.91 times higher than that of the surrounding connective tissue, the difference was highly significant (P <0.005). The concentrations of cisplatin in the peritoneum of single drug group and repeated drug group were 4.14 and 2.5 times higher than that of lymph node respectively, the difference was highly significant (P <0.005). The drug concentrations of iliac, obturator and abdominal lymph nodes were 2.27-fold, 2.75-fold and 2.54-fold, respectively, in the repeated administration group. The difference was also highly significant (P <0.005). Light microscope shows that the repeated administration of lymph node metastasis of cancer tissue liquefaction necrosis, only a single administration of lymph node reaction hyperplasia. Tip, cisplatin intraperitoneal small doses of short-term repeated administration, up to the drug accumulation effect, resulting in high efficiency and low toxicity, may become one of the methods of treatment of lymph node metastasis of ovarian cancer.