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近50年内,已有许多研究工作者从事于疟疾抗体的检查,许多工作都以发展能用于疟疾诊断和调查的血清学技术为中心。虽然近几年已经发展了几种有希望的血清学技术,但还没有一种能完全符合于上述目的的方法。【补体结合试验】早在1907年,DeBla-Si企图检出疟疾的抗体,用干燥的有疟原虫感染的红细胞作抗原进行了补体结合试验。Mircoli(1908)用洗涤的感染红细胞,Ferran-nini(1911)用感染的脾脏的水提取物和酒
In the past 50 years, many researchers have been engaged in the examination of malaria antibodies. Much work has been centered on the development of serological techniques that can be used in the diagnosis and investigation of malaria. Although several promising serological techniques have been developed in recent years, there is no method that exactly matches this goal. [Complement Binding Assay] As early as 1907, DeBla-Si attempted to detect malaria antibodies and performed a complement fixation assay using dry erythrocytes infected with Plasmodium as an antigen. Mircoli (1908) used washed infected erythrocytes, Ferran-nini (1911) used water extracts of infected spleen and wine