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为了从整体水平上研究PML RARα融合蛋白的致白血病作用 ,建立了仅在髓系细胞中表达PML RARα融合基因的转基因小鼠。通过表型分析发现一个单系的 3只hCG PML RARα转基因小鼠在 1- 5个月时发生急性早幼粒细胞白血病 ,从而说明PML RARα融合基因的表达在白血病的发生中起着极为重要的作用。
In order to study the leukemia effect of the PML RARα fusion protein on an overall level, transgenic mice expressing the PML RARα fusion gene only in myeloid cells were established. Through phenotypic analysis, a single line of 3 hCG PML RARα transgenic mice developed acute promyelocytic leukemia between 1 and 5 months, indicating that PML RARα fusion gene expression plays an important role in the development of leukemia. effect.