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目的探讨辛伐他汀对术后白细胞介素-1β(IL-1β)及认知功能障碍是否有影响,从而为临床提供参考。方法选择72只雄性SD大鼠随机分为对照组(A组)和实验组(B组),各36例。对照组(A组)用生理盐水喂饲7 d,实验组(B组)用辛伐他汀(10 mg/kg)喂饲7 d。在喂饲7 d后行切脾手术,A、B组随机分为4个亚组(A0、A1、A3、A7组和B0、B1、B3、B7组,n=9)分别于术前和术后第1、3、7天通过Y型迷宫测试大鼠的认知功能及检测外周血IL-1β表达。结果术后各亚组认知功能比较差异无统计学意义(P>0.05),对照组中IL-1β水平手术与非手术组比较差异无统计学意义(P>0.05),实验组与对照组比较差异无统计学意义(P>0.05)。结论切脾手术未能引起青年鼠术后认知功能障碍,也未能使青年鼠外周血IL-1β水平升高。辛伐他汀可能并不抑制外周IL-1β的水平,对术后认知功能障碍的发生也无影响。
Objective To investigate whether simvastatin exerts influence on postoperative IL-1β and cognitive dysfunction, so as to provide a reference for clinical practice. Methods Seventy-two male SD rats were randomly divided into control group (group A) and experimental group (group B), with 36 cases each. The control group (group A) was fed with saline for 7 days. The experimental group (group B) was given simvastatin (10 mg / kg) for 7 days. The rats in group A and B were randomly divided into 4 subgroups (A0, A1, A3, A7 and B0, B1, B3 and B7, n = 9) On the 1st, 3rd, 7th day after operation, the cognitive function of the rats was tested by Y-maze and the expression of IL-1β in peripheral blood was detected. Results There was no significant difference in cognitive function among all subgroups after operation (P> 0.05). There was no significant difference between the control group and the non-surgical group (P> 0.05) The difference was not statistically significant (P> 0.05). Conclusion Incision spleen surgery failed to induce cognitive dysfunction in young rats and did not increase the level of IL-1β in peripheral blood of young mice. Simvastatin may not inhibit the level of peripheral IL-1β, postoperative cognitive dysfunction also had no effect.