以苯扎隆为起始原料,经溴化反应,重结晶得到苯溴马隆晶体。该工艺操作简便、成本低,用乙醇作为溴化溶剂来替代以往文献报导的腐蚀性强的冰醋酸溶剂,条件温和、适合工业化生产,总收率可达85%,制得的产品含量可达99.8%(滴定法),单一杂质小于0.1%,优于欧洲药典质量标准。 Benzalon as the starting material, the bromination reaction, recrystallization benzbromarone crystals. The process is simple, low cost, ethanol as a brominated solvent to replace the previously reported strong corrosive glacial acetic acid solvent, mild conditions, suitable for industrial production, the total yield of up to 85%, the product content up to 99.8% (titration), single impurity less than 0.1%, better than the European Pharmacopoeia quality standards.