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本文对复方木香注射液的药理作用进行了初步实验研究。当药物浓度为1.0×10~(-3)～2.4×10~(-2)g/ml时,对各种动物(家兔、豚鼠、大鼠和小鼠)离体肠肌活动有明显的抑制作用;对乙酰胆碱、组胺及氯化钡所致的肠肌收缩有明显的对抗作用。在体肠(家兔、大鼠)实验表明,静脉注射复方木香注射液2～8g/kg,可使血压迅速上升,肠蠕动抑制,但呼吸无明显影响。小鼠口服给药能明显增强胃肠道推进机能。此外,经扭体法和热板法实验,表明该注射液还具有明显的镇痛作用;小鼠口服、腹腔注射及静脉注射100g/kg均无明显毒性反应。
In this paper, a preliminary experimental study was conducted on the pharmacological effects of Compound Muxiang Injection. When the drug concentration was 1.0×10~(-3)~2.4×10~(-2)g/ml, the activity of isolated intestinal muscle was obvious in various animals (rabbits, guinea pigs, rats and mice). Inhibitory effect; obvious antagonistic effect on acetylcholine, histamine and barium chloride induced intestinal muscle contraction. Intestines (rabbits, rats) experiments show that intravenous injection of compound wood injection 2 ~ 8g/kg, can make the rapid increase in blood pressure, bowel movement inhibition, but no significant effect on respiration. Oral administration to mice significantly enhanced gastrointestinal propulsion. In addition, the writhing and hot plate experiments showed that the injection also has obvious analgesic effect; no toxic reaction was found in mice by oral, intraperitoneal injection and intravenous injection of 100g/kg.