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细胞毒药物是一类具有致癌、致畸、生殖毒性、低剂量时可致系列器官毒性的药物。随着对细胞毒药物危害的认识加深,自20世纪90年代我国逐步建立以配置细胞毒药物为主的静脉用药调配中心(PIVAS)。由于细胞毒药物的特殊性,其在临床的正确使用至关重要。这就要求PIVAS药师对药物有深入的了解,如配置药品的溶媒、推荐剂量、给药途径、给药时间、静脉滴注速度、药物之间相互作用等。本文对PIVAS药师在审核医嘱中发现的不合理用药进行分析,有效提高了调配医嘱的准确性,有助于减少不合理医嘱,保证患者用药安全、有效。
Cytotoxic drugs are a class of carcinogenic, teratogenic, reproductive toxicity, low doses can cause a series of organ toxicity drugs. With the deepening of the awareness of the dangers of cytotoxic drugs, since the 90s of the 20th century in our country, a center for the deployment of intravenous drugs mainly consisting of cytotoxic drugs has been established (PIVAS). Due to the particularity of cytotoxic drugs, its proper clinical use is crucial. This requires PIVAS pharmacists have a deep understanding of drugs, such as the allocation of drugs in the media, the recommended dose, route of administration, administration time, intravenous infusion rate, the interaction between drugs. In this paper, PIVAS pharmacists in the examination of the doctor’s orders found in the irrational use of drug analysis, effectively improve the accuracy of deployment of medical advice, help to reduce unreasonable doctor’s advice to ensure that patients medication safe and effective.