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高效液相色谱法测定盐酸依托必利片剂中的盐酸依托必利的含量。色谱柱:Phenomenex-C18(4.60×250mm);流动相:0.05mol·L-1醋酸钠溶液(用冰醋酸调节pH值至5.0)-甲醇(60∶40);流速:1.0mL.min-1;检测波长:258nm。回归方程为:y=533928.10866x+296386.4578,r=0.9992,线性范围为4.216—42.16μg·mL-1,回收率为99.56%—100.37%,RSD为0.33%。本法简便、准确、灵敏。
Determination of Etopride Hydrochloride in Etophoric Hydrochloride Tablets by High Performance Liquid Chromatography. Column: Phenomenex-C18 (4.60 × 250 mm); mobile phase: 0.05 mol·L-1 sodium acetate solution (adjusted to pH 5.0 with glacial acetic acid) -methanol (60:40); flow rate: 1.0 mL · min- Detection wavelength: 258nm. The regression equation was: y = 533928.10866x + 296386.4578, r = 0.9992, the linear range was 4.216-42.16μg · mL-1, the recoveries were 99.56% -100.37%, RSD was 0.33%. This law is simple, accurate and sensitive.